Date Progress Report/Journal Club
06-May-13 陳怡萍 Ping Cloning and Expression of the DNMT3a
Dr.李家隆 Li A role for the Perlman syndorm exonuclease Dis312 in the Lin28-let-7 pathway
13-May-13 Dr.林亮儒 Jason  Corporative activity of CPS-6 and WAH-1 is regulated by redox potential in mitochondria
Dr. 郭邦賢 Benjamin  The dual functions of the extreme N-terminus of  TDP-43 in regulating its biological activity and inclusion formation
20-May-13 楊維仁 Godzella hSN4/SN4 crystal structure and CshA SAXS
陳怡臻 Yichen Structural and functional studies of TatD in DNA binding and degradation
03-Jun-13 江建豪 Hao Wide Search Molecular Replacement (For NTD-RRM12)/Crystallization of NTD from hTDP-43
易婉莉 Lilian Structures of human exonuclease I DNA complexs suggest a unified mechanism for nuclease family
10-Jun-13 Dr.蕭育源 Mike How to make a movie by pymol ? And A new structural movie for RNase T paper
陳怡萍 Ping The mammalian de novo DNA methyltransferases DNMT3A and DNMT3B are also DNA 5-hydroxymethylcytosine dehydroxymethylases./DNA 5-Methylcytosine Demethylation Activities of the Mammalian DNA Methyltransferases
17-Jun-13 黃冠偉 Wei  Identification of the Inhibitors for the DnaQ-like exonucleases
朱利亞 Julia 
24-Jun-13 杜莉雲 Yulander Identification of Labile Zn-Sites in Zn-finger Proteins
楊維仁 Godzella Ring around the Ro-sie RNA-Mediated
08-Jul-13 易婉莉 Lilian
黃冠偉 Wei Identification of the Inhibitors for the DnaQ-like exonucleases_revised
15-Jul-13 Dr.蕭育源 Mike How_to get_crystals
29-Jul-13 Dr. 郭邦賢 Benjamin
江建豪 Hao Inhibition of TDP-43 Aggregation by Nucleotic Acid binding
05-Aug-13 姜心喜 Cynthia Interaction between PNPase and CshA
周竹君 Purification of mDNMT3a and mDNMT3l complex
02-Sep-13 Dr.李家隆 Li  Toward the complex structural study of human PNPase and its interacting helicase hSUV3
杜莉雲 Yulander Structure Basis for Dimerzation in DNA Recognition by Gal4
09-Sep-13 朱利亞 Julia Structural study of RNase R in RNA degradation
Dr.林亮儒 Jason Identification and Characterization of Disulfide Bonds in Proteins and Peptides from Tandem MS Data by Use of the MassMatrix MS/MS
16-Sep-13 陳怡萍 Ping Expression, purification and assembly of Dnmt3a/3l heterotetrameric complex
Dr.李家隆 Li The assembly and distribution in vivo of the Escherichia coli RNA degradosome
23-Sep-13 Dr.林亮儒 Jason Unraveling the molecular mechanism for the co-operative action of CPS-6/ EndoG and WAH-1/ AIF  
易婉莉 Lilian ABC ATPase signature helices in Rad50 link nucleotide state to Mer11 interface for DNA repair
30-Sep-13 楊維仁 Godzella Preliminary of Crystallization of Nanoarchaeum equitans Topoisomerase VI, Improvement of cTudor-SN functional analysis
Dr. 郭邦賢 Benjamin
07-Oct-13 江建豪 Hao 1. SAXS analysis of NTD-RRM12 with TG repeats DNA 2. Crystallization of NTD from hTDP-43
陳怡萍 Ping  Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation
14-Oct-13 杜莉雲 Yulander Characterization and purification of  human polynucleotide phosphorylase (hPNPase)
朱利亞 Julia Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay
28-Oct-13 易婉莉 Lilian  SAXS analysis of CshA with / without ATP/RNA unwinding activity of CshA 
楊維仁 Godzella Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis
04-Nov-13 Dr. 郭邦賢 Benjamin Structural basis for recognition of the UG-rich RNA by TDP-43 revealed by the crystal structure of RRM1-DNA complex
江建豪 Hao Ab initio shape determination by simulated annealing (SA) using a multiphase dummy atom model
11-Nov-13 Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
杜莉雲  Yulander Non-coding Y RNAs as ththers and gates insights form bacteria
18-Nov-13 朱利亞 Julia
Dr.林亮儒 Jason Prediction of localization and interactions of apoptotic proteins
25-Nov-13 陳怡萍 Ping Expression, purification and assembly of Dnmt3a/3l heterotetrameric complex
Dr.李家隆 Li Discrimination of RNA form DNA by Polynucleotide Phosphorylase 
16-Dec-13 Dr.林亮儒 Jason Molecular basis for cell-killing and survival activity of CPS-6 is modulated by oxidative stress
Dr. 郭邦賢 Benjamin Molecular basis of UG-rich RNA recognition by the human splicing factor TDP43
23-Dec-13 楊維仁 Godzella Improvement of cTudor-SN functional analysis
陳怡萍 Ping Inactive DNMT3B Splice Variants Modulate De Novo DNA Methylation
30-Dec-13 江建豪 Hao Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
朱利亞 Julia  Structure and RNA-binding properties of the Not1–Not2–Not5 module
06-Jan-14 杜莉雲 Yulander Progress Report ( hPNPase, Drb1, RNaseT )
楊維仁 Godzella Refinement against twinned data by Phenix
20-Jan-14 Dr. 郭邦賢 Benjamin Developmentally regulated RNA-binding protein 1 (Drb1),a neural RRM-type RNA-binding protein, also called RNA-binding protein motif 45 (RBM45)
27-Jan-14 Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
10-Feb-14朱利亞 Julia  Structural study of RNase R in RNA degradation 
17-Feb-14陳怡萍 Ping  Purification of  Geobacillus sp. PNPase and CshA 
24-Feb-14Dr.林亮儒 Jason Molecular basis for cell-killing and survival activity of EndoG/CPS-6 is modulated by exidative stress
03-Mar-14楊維仁 Godzella  New Mechanistic and Functional Insights into DNA Topoisomerases
10-Mar-14江建豪 Hao Crystal structure of  hRRM1-D169G and ssDNA
17-Mar-14Dr. 郭邦賢 Benjamin  Stabilization of a b-hairpin in monomeric Alzheimer’s amyloid-b peptide inhibits amyloid formation
24-Mar-14Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
31-Mar-14朱利亞 Julia  Structural basis for RNA unwinding and degradation by RNase R
21-Apr-14Dr. 禤佳瑋 Jennifer Huen Structural and Functional Characterization of the yeast AAA+ ATPases Rvb1 and Rvb2 
28-Apr-14Armin Golzar RNase R human homologues hDis3, hDis3L1 and hDis3L2
05-May-14杜莉雲 Yulander  Induced tRNA Import into Human Mitochondria:Implication of a Host Aminoacyl-tRNA-Synthetase    
12-May-14陳怡萍 Ping Direct Decarboxylation of 5-Carboxylcytosine by DNA C5-Methyltransferases 
19-May-14Dr.林亮儒 Jason EndoG/CPS-6: An endonuclease that is involved in mitochondrial biogenesis (life) and apoptosis (death)
26-May-14楊維仁 Godzella Functional analysis of Tudor-SN protein
09-Jun-14朱利亞 Julia Structural basis for RNA unwinding and degradation by RNase R
16-Jun-14江建豪 Hao TDP-34 progress report
23-Jun-14Dr. 郭邦賢 Benjamin Aggregation of TDP-43-RRM2 and the purification of RRM domains of Drb1
30-Jun-14Dr.李家隆 Li  Toward the complex structural study of human PNPase and its interacting helicase hSUV3
07-Jul-14Dr.禤佳瑋 Jen Investigations of the DEAD-box helicase CshA of G. kaustophilus in RNA degradation
14-Jul-14江建豪 Hao Structural and biochemical characterization of the ALS-linked TDP-43 mutant
21-Jul-14杜莉雲 Yulander Identification of Labile Zn-Sites (PML & HCV) with different Drugs
28-Jul-14陳怡萍 Ping  Expression, purfication and assembly of Dnmt3a-Dnmt3l complex
18-Aug-14Dr.林亮儒 Jason ROS link to cell death via modulation of the Endonuclease G (EndoG) activity
25-Aug-14楊維仁 Godzella  The Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression
01-Sep-14朱利亞 Julia  Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation  
白乙晨  Co-Crystallization of human polynucleotide phosphorylase(hPNPase) with RNA
26-Sep-14江建豪 Hao Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients
03-Oct-14Dr. 郭邦賢 Benjamin Out-of-register B-sheets suggest a pathway to toxic amyloid aggregates
17-Oct-14Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
31-Oct-14Dr.禤佳瑋 Jen  Investigations of the DEAD-box helicase CshA of Geobacillus sp. in RNA degradation
07-Nov-14Armin Golzar hDis3 and inhibitor of hPNPase
14-Nov-14杜莉雲 Yulander Complex structural study of E. coli TatD and ssDNA
28-Nov-14陳怡萍 Ping Structural insight into autoinhibition and histone H3-induced activation of DNMT3A
Rajesh Crystallization of hPNPase
05-Dec-14Dr.林亮儒 Jason  EXOG, a novel paralog of Endonuclease G in higher eukaryotes 
12-Dec-14楊維仁 Godzella Functional and structural analysis of Tudor-SN protein ( recent data )
26-Dec-14江建豪 Hao Structural basis for the ALS-linked TDP-43 mutant is more susceptible for protein processing leading to accelerated aggregation
09-Jan-15Dr. 郭邦賢 Benjamin
16-Jan-15Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
23-Jan-15Dr.禤佳瑋 Jen  Structural and functional characterization of the DEAD-box helicase CshA of Geobacillus species
30-Jan-15杜莉雲 Yulander Crystal structures of human polynucleotide phosphorylase(hPNPase) complex with different types of RNAs ( 5S rRNA, RNase P RNA, MRP RNA)
06-Feb-15陳怡萍 Ping Expression & Purification of Human Mitochondrial Polyadenylation Polymerase (hmtPAP)
13-Feb-15Dr.林亮儒 Jason The crystal structures of CPS-6 and DNA and RNA complexes
09-Mar-15

楊維仁 Godzella Overall shape of Tudor-SN determination via SAXS, DLS, AUC and MALS 


16-Mar-15朱利亞 Julia Structural basis for RNA unwinding and degradation by RNase R
23-Mar-15江建豪 Hao The cleavate pattern of TDP-43 determines it rate of clearance and cytotoxicity
13-Apr-15Dr. 郭邦賢 Benjamin TDP-43 N terminus encodes a novel ubiquitin-like fold and it unfolded form in equilibirum that can be shifted by binding to ssDNA
20-Apr-15Dr.李家隆 Li  Toward the complex structural study of human PNPase and its interacting helicase hSUV3

27-Apr-15Dr.禤佳瑋 Jen Structural and functional characterization of the DEAD-box helicase CshA of Geobacillus species
Shashank Developmentally regulated RNA-binding protein 1 (Drb1),orRNA-binding protein motif 45 (RBM45)
04-May-15Armin Golzar Ribonucleases As a Novel Therapeutic Target in Bacteria
18-May-15杜莉雲 Yulander Molecular recognition of RhlB and RNase D in the Caulobacter crescentus RNA degradosome
25-May-15Dr.林亮儒 Jason Endonuclease G (EndoG) is a ROS sensor in regulating life and death of a cell
08-Jun-15陳怡萍 Ping Cloning, Expression & Purification of Human REXO2 (RNA exonuclease 2)
15-Jun-15楊維仁 Godzella  Procedure  progress of overall Tudor-SN studies so far
22-Jun-15Armin Golzar Designing MexAB-OprM efflux pump inhibitors in Pseudomonas aeruginosa ( non-thesis-proposal)
06-Jul-15江建豪 Hao1. Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.

13-Jul-15Dr. 郭邦賢 Benjamin Low molecular weight species of TDP‑43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death
20-Jul-15Dr.李家隆 Li Structure of the hexameric ​HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea
27-Jul-15Dr.禤佳瑋 Jen/Evelin Structural and functional characterization of the DEAD-box protein CshA of Geobacillus species
Evelyn Structure and Binding Properties of CshA – a DEAD Box Protein
10-Aug-15Shashank RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
31-Aug-15Dr.林亮儒 Jason The crystal structures of CPS-6 and DNA complexe
16-Sep-15陳怡萍 Ping Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I
23-Sep-15楊維仁 Godzella Combination of HPLC/SAXS/MALS for analysis the flexible shape of Tudor-SN
陳怡萍 Ping High-Pressure Refolding
30-Sep-15Armin Gozar hPNPase regulate RNA import into mitochondria 
07-Oct-15江建豪 Hao Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations
14-Oct-15Dr. 郭邦賢 Benjamin TDP-35 sequencsters TDP-43 into cyroplasmic inclusions through binding with RNA
21-Oct-15Dr.李家隆 Li  Toward the complex structural study of human PNPase and its interacting helicase hSUV3
28-Oct-15Dr.禤佳瑋 Jen  Diivision of Labor in a Oligomer of the DEAD-Box RNA Helicase Ded1p
18-Nov-15Shashank RNA-binding protein motif 45 (RBM45) or Developmentally regulated RNA-binding protein 1 (Drb1)
25-Nov-15吳秋儒 The study of mSUV3 and mPNPase
02-Dec-15Dr.禤佳瑋 Jen Structural insights into the dimeric DEAD-box helicase CshA in RNA binding and unwinding ( RNA monthly meeting)
16-Dec-15Dr.李家隆 Li hPNPase negative stain raw data
21-Dec-15Shashank Structural and biochemical studies of the RNA-binding protein RBM45 in neurologic disorders ( TIGP-MCB)
23-Dec-15Dr.林亮儒 Jason Structural based study for CPS-6 and DNA interactions
陳怡萍 Ping Crystallization of Human REXO2 (RNA exonuclease 2)
30-Dec-15楊維仁 Godzella cTudor-SN shape determination by HPLC-SAXS/Dimer structure of hPNPase
27-Jan-16Dr.李家隆 Li  Toward the complex structural study of human PNPase and its interacting helicase hSUV3
03-Feb-16Dr.禤佳瑋 Jen  Structural insights into Cold Shock helicase A (CshA), a unique dimeric DEAD-box helicase containing an essential RNA binding C-terminal domain
26-Feb-16Shashank Cloning, Expression and Purification of Arabidopsis thaliana Mitochondria and Chloroplast PNPase
25-Mar-16Dr.林亮儒 Jason EndoG gene expression and regulation
01-Apr-16楊維仁 Godzella Calculate SAXS curve form pdb file to higher order structure  by  SAXS/Crystal Structure of hREXO2  ~ Ping’s project
08-Apr-16陳怡萍 Ping Crystal Structure of Human REXO2 (RNA exonuclease 2)
07-May-16Dr.李家隆 Li  Toward the complex structural study of human PNPase and its interacting helicase hSUV3
27-May-16Dr.禤佳瑋 Jen  Structual insights into catalysis and dimerization enhanced exonuclease activity of RNase J
22-Jul-16Dr.林亮儒 Jason Crystal structure of Endo G in complex with DNA revealing how it degrades DNA nonspecifically as a homodimer 
29-Jul-16楊維仁 Godzella Crystal structure of hREXO2 bound with ssDNA substrates
05-Aug-16陳怡萍 Ping Human REXO2 (RNA exonuclease 2)
12-Aug-16Armin Gozar Degradosome in gram negative bacteria
26-Aug-16Dr. 郭邦賢 Benjamin TDP-43, RBM45 and FUS
廖怡玟 Characterization of the thermal stability of the disease-linked TDP-43 mutant K263E
23-Sep-16Dr.吳權娟 Chuan Chuan Wu Structural and functional studies of  human mitochondrial Endo G and EXOG
06-Oct-16朱利亞 Julia Yeast Exo9 forms complex with Rrp44 and Rrp6 in Nucleus and cytosol
13-Oct-16

Shashank Developmentally Regulated RNA-binding Protein1 (Drb1)/ RNA-binding Motif Protein 45 (RBM45), a Nuclear Cytoplasmic Trafficking Protein, Forms TAR DNA-binding Protein 43 (TDP-43)-mediated Cytoplasmic Aggregates


20-Oct-16吳秋儒  The study of mSUV3 and mPNPase
10-Nov-16Dr.林亮儒 Jason Structural insights into mitochondrial Endonuclease G under oxidative stress 
24-Nov-16楊維仁 Godzella Crystal structure of hREXO2 bound with ssDNA/RNA
01-Dec-16陳怡萍 Ping Human REXO2 (RNA exonuclease 2)
08-Dec-16Armin Gozar Human PNPase progress report
15-Dec-16Dr. 郭邦賢 Benjamin In-vitro prion-like behaviour of TDP-43 in ALS
22-Dec-16Dr. 吳權娟 Chuan Chuan Wu Structural and functional studies of human mitochondrial EndoG-like endo/exonuclease (EXOG)
29-Dec-16Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3 ( SAXS)
05-Jan-17朱利亞 Julia Crystal Structure Of Silkworm Piwi-clade Argonaute Siwi Bound To piRNA
12-Jan-17Shashank RNA-recognition motifs (RRMs) in disease-linked RNA-binding proteins
23_Feb_17Dr. 林亮儒 Jason Structural insights into mitochondrial Endonuclease G under oxidative stress
14-Mar-17楊維仁 Godzella Over view of structural information of hREXO2 bound with ssDNA/RNA
21-Mar-17陳怡萍  Ping Crystallization of Human SUV3
28-Mar-17 Dr. 郭邦賢 Benjamin ALS-causing cleavages of TDP-43 abolish its RRM2 structure and unlock CTD for enhanced aggregation and toxicity
11-Apr-17Dr. 吳權娟  Chuan Chuan Wu Structural insights of Exonuclease G (EXOG) in complexed with dsDNA
25-Apr-17Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
02-May-17朱利亞 Julia Structure and functional studies of human Rexo2 
23-May-17Dr.林亮儒 Jason Stimulating mitochondrial Endonuclease G by resveratrol and natural stilbenoids
13-Jun-17 楊維仁 Godzella Resource in our Lab For Crystallographic studies
27-Jun-17陳怡萍 Ping Crystallization of Human SUV3
04-Jul-17Dr. 郭邦賢 Benjamin Review and New
11-Jul-17Dr.吳權娟  Chuan Chuan Wu  A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease
25-Jul-17Armin Gozar The human mitochondrial
01-Aug-17Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
15-Aug-17Shashank Biophysical properties for the RNA-recognition motifs of the disease-linked RNA-binding proteins
22-Aug-17陳郁淳 Reconstitution a human mitochondrial complex PNPase-SUV3-mtPAP in RNA turnover
Wilson Purification and Structure of REXO2
14-Sep-17Dr.林亮儒 Jason The regulatory role of the dimeric  interface of the Endonuclease G
28-Sep-17楊維仁 Godzella Structural and functional characterization of oligoribonuclease protein
04-Oct-17陳怡萍 Ping  Crystallization of Human SUV3
19-Oct-17Armin Gozar Impact of disease-Linked mutations on oligomerization state, activity and structure of human PNPase
26-Oct-17Dr.吳權娟 Chuan Chuan Wu Structural insights into ExoG in mitochondrial genome maintenance
02-Nov-17Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
17-Nov-17唐偉軒 Sarah Measuring the enzyme activity of mitochondria helicase Suv3
30-Nov-17Dr.林建竹 Ken Structures of mammalian DNA methyltransferase 3A (DNMT3A)-DNA complex in DNA methylation and demethylation
27-Dec-17Dr.吳權娟 Chuan Chuan Wu EXOG activity assay with RNA
12-Jan-18Dr.林亮儒 Jason The regulatory role of the dimeric interface of Endonuclease G
19-Jan-18楊維仁 Godzella  project briefing 1. hREXO2 2. Geobacillus CshB 3. TDP-43 N100
26-Jan-18Saimoon  Small Scale Expression of RBM45 Protein
31-Jan-18陳怡萍 Ping Structure of mtEXO
07-Feb-18Armin Golzar Crystal structure of the dimeric human PNPase revealing why the disease-linked mutants suffer with low RNA import and degradation activities
14-Mar-18Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
28-Mar-18朱利亞 Julia Structure basis of Rexo2 in RNA degradation
11-Apr-18Sashank Function of Human REXO2
18-Apr-18唐偉軒 Sarah  Structural and Biochemical Studies of Human Mitochondria Helicase Suv3
03-May-18Monika DEAD-box RNA helicase CshB from Gram-positive bacteria Geobacillus stearothermophilus in RNA degradation
10-May-18Dr.林亮儒 Jason The functional role of the apoptosis inducing factor (AIF) in the folding stability of the dimeric Endonuclease G (EndoG)
17-May-18楊維仁 Godzella Pathogenic fibrils assembled by short peptides generated form dissected TDP-43 
30-May-18陳怡萍 Ping Expression & Purification of Human endonuclease G
06-Jun-18Armin Golzer Structural insight into the dimeric human PNPase revealing why the disease-linked mutants suffer with low RNA import and degradation activities
13-Jun-18Dr.吳權娟 Chuan Chuan Wu  Studies of human ExoG function in mitochondrial DNA maintenance
20-Jun-18Dr.李家隆 Li Toward the complex structural study of human PNPase and its interacting helicase hSUV3
11-Jul-18Sashank  RRM domains in protein aggregation and Neurodegeneration
25-Jul-18唐偉軒 Sarah  Structural and Biochemical Studies of Human Mitochondria Helicase Suv3
01-Aug-18Dr.林建竹 Ken Structural basis for CpG-specific DNA methylation of DNMT3B
29-Aug-18陳怡萍 Ping Expression & Purification of Human endonuclease G
沈凱哲 Kai Che Shen 
05-Sep-18Dr.Armin Polynucleotide phosphorylase (PNPase) review
17-Oct-18Sashank TDP-43 in neurodegenerative diseases
24-Oct-18唐偉軒 Sarah Dicer uses distinct modules for recognizing dsRNA termini
31-Oct-18Dr.林建竹 Ken Structural basis for CpG-specific DNA methylation of DNMT3B
13-Nov-18Dr.林亮儒 Jason Endonuclease G (EndoG) and its potential roles in the oxidized DNA removal and repair in mitochondria 
21-Nov-18楊維仁 Godzella Pathogenic protofilaments assembled by short peptides generated form dissected TDP-43  ?? 
28-Nov-18陳怡萍 Ping Crystallization of the Salmonella F41 Fragment of Flagellin with sdAb
16-Jan-19
Sashank Disease linked mutations in RNA-recognition motifs of TDP-43

16-Jan-19
Monika  Reconstitution a human mitochondrial complex PNPase-SUV3-mtPAP in RNA turnover

23-Jan-19
 唐偉軒 Sarah Optimization of Human Mitochondria Helicase Suv3 for Crystallization
20-Feb-19
 Dr.林建竹 Ken Structural basis for CpG-specific DNA methylation of Human DNMT3B
05-Mar-19
 Sarooj Nadeem Study of DNA methyltransferase DNMT3B and DNMT3L
08-Mar-19
 Dr.林亮儒 Jason Endonuclease G (EndoG) and its potential roles in the oxidized DNA removal and repair in mitochondria 

15-Mar-19
 楊維仁 Godzella Cryo-EM Structure of TDP-43 (TAR DNA binding protein 43k ) polymorphic fibrils
22-Mar-19
 陳怡萍 Ping Expression & Purification of Human endonuclease G
29-Mar-19
 Dr.Armin Golzer PNPase Regulates RNA Import into Mitochondria
12-Apr-19
 Dr.吳權娟 Chuan Chuan Wu Structural study of human mitochondrial DNA (mtDNA) degradation machinery and its role in mtDNA maintenance
19-Apr-19
 朱利亞 Julia Structure of the 80S ribosome-Xrn1 nuclease complex
26-Apr-19
 Sashank How does TDP-43 participate in both reversible stress granule assembly and irreversible pathogenic assembly?
03-May-19
 唐偉軒 Sarah Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36
10-May-19
 Dr. 林建竹 Ken Structural insights into CpG-specific DNA methylation by human DNA methyltransferase DNMT3B

24-May-19
 Dr. 林亮儒 Endonuclease G (EndoG) and its roles in ROS damaged mtDNA processing in mitochondria 

14-Jun-19
 楊維仁 Godzella  Drug Design Strategies on Enterovirus71  2A protease
SabarBudiman Reconstitute Human Mitochondrial RNA Degradosome mtPAP, SUV3, and PNPase Involved in RNA Turnover
07-Aug-19
 Monika Biochemical and structural characterization of human PNPase in RNA degradation and RNA import in mitochondria  ( Qualifying Exam)

14-Nov-19
 Cindy Target-Effector Drug Design an example of designing high specific drugs against EV-71
07-Feb-20
 林群融 Roy Characterization of the DNA methyltransferase inhibitors by biochemical and structural approaches
14-Feb-20
 陳怡萍 Ping Human endonuclease G reconstruction , purification and crystallization

24-Feb-20
 Dr. 吳權娟 Chuan Chuan Wu Structural studies of human mtDNA degradosome
03-Mar-20
 Dr. Armin Golzer PNPase RNA import vs. RNA turnover

16-Mar-20
 Dr. 林建竹 Ken DNMT3B-3L-Nucleosome complex
01-Jun-20
 Monika Biochemical and structural characterization of PNPase-Suv3 complex in RNA degradation in human mitochondria
08-Jun-20
 Dr. 林亮儒 Jason Endonuclease G (EndoG) and its functional role in mitochondrial DNA maintenance

15-Jun-20
 楊維仁 Godzella Peptide inhibitor design for EV71  2Apro

29-Jun-20
 林群融 Roy Characterization of the DNA methyltransferase inhibitors by biochemical and structural approaches
06-Jul-20陳怡萍 Ping Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function
20-Jul-20Dr. Armin PNPase RNA import vs. RNA turnover
03-Aug-20Dr. 林建竹 Structural Mechanism of DNMT3B-3L DNA Methylation mediated by Nucleosome modification
24-Aug-20楊維仁 Godzella Zn ejector design for two cysteine protease SARS-CoV-2  PLpro and EV71 2Apro
31-Aug-20林群融 Roy Characterization of the DNA methyltransferase inhibitors by biochemical and structural approaches
14-Sep-20陳怡萍 Ping Faster and Easier Cloning
21-Sep-20Dr. Armin Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA
28-Sep-20費正尹 Tony Zn-ejector can be used to target nsp13 and nsp14 of SARS-CoV-2
05-Oct-20Monika Biochemical and structural characterization of PNPase-Suv3 complex in RNA degradation in human mitochondria
02-Nov-20楊維仁 Godzella  Peptide inhibitor design for EV71  2Apro
林群融 Roy  SIRT1 is downregulated by autophagy in senescence and ageing
16-Nov-20Dr. 卓昭成 David Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation
23-Nov-20陳怡萍 Ping Expression and Purification of the Two Putative DNMTases in Trichoderma reesei ~TrDIM2 and TrRID1
30-Nov-20Dr. Armin PNPase RNA import vs. RNA turnover
07-Dec-20費正尹 Tony Zn-ejector can be used to target nsp13 and nsp14 of SARS-CoV-2
26-Dec-20Dr. 林亮儒 Jason Mitochondrial EndoG is a key effector of resveratrol that modulates its nuclease activity on ROS damaged DNA degradation
04-Jan-21楊維仁 Godzella Introduction of Light Scattering Technology
11-Jan-21林群融 Roy Characterization of the DNA methyltransferase inhibitors by biochemical and structural approaches
18-Jan-21Dr. 卓昭成 David Structural and biochemical studies of the auto-regulation mechanism of DNA methyltransferase 3B
25-Jan-21

陳怡萍 Ping Expression and Purification of Human CAD and ICAD

22-Feb-21Dr. Armin PNPase RNA import vs. RNA turnover
15-Mar-21Monika How Suv3 helicase participates in RNA turnover and DNA metabolism in mitochondria
12-Apr-21楊維仁 Godzella Structural Characterization of Aggregation-Prone Human TDP-43
23-Apr-21林群融 Roy Structure of  nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
03-May-21Dr. 卓昭成 David Crystal structure of human DNA methyltransferase 3B in complex with harmine provides insights into mode of inhibition
10-May-21陳怡萍 Ping Expression and Purification of Human CAD and ICAD
29-Jul-21Dr. Armin PNPase RNA import vs. RNA turnover
02-Aug-21費正尹 Tony Solving the structure of DNMT3B214 and confirm the demethylation activity of its R826A mutant.
09-Aug-21Monika How Suv3 helicase participates in RNA turnover in mitochondria
16-Aug-21Dr. 林亮儒 Jason Mitochondrial Endonuclease G is stimulated by resveratrol in degrading damaged DNA
23-Aug-21楊維仁 Godzella Dual Strategies to Inhibit Enterovirus 71 2A Protease:  Novel Peptide Inhibitors Development and Drug Repurposing of Zn-ejector Drugs
30-Aug-21林群融 Roy Characterization of the DNA methyltransferase inhibitors by biochemical and structural approaches
09-Sep-21Dr. 卓昭成 David The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation
16-Sep-21陳誼寧 Moog Construction of cryo-electron microscope data analysis hardware and system
23-Sep-21Dr. 李宜靜 Yi-Ching Li  Structural studies of caspase-activated DNase (CAD) and dinucleosome complex
30-Sep-21陳怡萍 Crystal structure of the mouse endonuclease G
07-Oct-21費正尹 Zn-ejector can be used to target nsp13 and nsp14 of SARS-CoV-2
14-Oct-21Monika How Suv3 helicase participates in RNA turnover in mitochondria
21-Oct-21Dr. 林亮儒 Jason Mechanisms of replication and repair in mitochondrial DNA deletion formation
28-Oct-21楊維仁 Godzella Crystal structure of human EndoG and apo-hSUV3
12-Nov-21林群融 Roy Characterization of the DNA methyltransferase inhibitors by biochemical and structural approaches
26-Nov-21Dr. 卓昭成  David Structural and biochemical studies of the auto-regulation mechanism of DNA methyltransferase 3B
14-Jan-22陳誼寧 Moog  Construction of cryo-electron microscope data analysis hardware and system
11-Feb-22黃薰禾 Daniel Structural and biochemical investigation of the prostate cancer-related mutants of human DNA methyltransferase 3B
18-Feb-22呂文廷 Lucia Structural and Biochemical Study of mitochondrial Human endonuclease G
25-Feb-22陳怡萍 Ping Expression and Purification of the Two Putative DNMTases in Trichoderma reesei ~TrDIM2 and TrRID1
04-Mar-22費正尹 Tony Structural and biochemical elucidations of ICF syndrome-related DNMT3B mutants that affects its oligomeric state and flanking sequence preference for target DNA
18-Mar-22Monika Jain  Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay.
25-Mar-22Dr.林亮儒  Jason Trans-resveratrol stimulates mitochondrial Endonuclease G to degrade damaged DNA
01-Apr-22楊維仁 Godzella Characterization of human EndoG crystal structure
08-Apr-22Dr.卓昭成  David Structural and biochemical studies of the auto-regulation mechanism of DNA methyltransferase 3B
15-Apr-22陳誼寧 Moog  CR-I-TASSER: assemble protein structures from cryo-EM density maps using deep convolutional neural networks 
22-Apr-22Dr. 李宜靜 Yi-Ching Li Cryo-EM single particle analysis of  hPNPase-RNA complex
29-Apr-22黃薰禾 Daniel DynamicelF3a O-GlcNAcylaiton controls translation reinitation during nutrient stress 
06-May-22呂文廷 Lucia Endonuclease G  promotes autophagy by suppressing mTOR signaling and activiing the DNA damage response
11-May-22Monika Jain Structural and biochemical insights into mitochondrial  RNA decay promoted by Suv3 helicase
17-Jun-22陳怡萍 Ping Human endonuclease G reconstruction , purification and crystallization
01-Jul-22費正尹 Tony Structural of the DNMT3B ADD domain suggests the absence of a DNMT3A-like autoinhibitory mechanism
15-Jul-22Monika Jain Structural and functional study of human Suv3 helicase in mitochondrial RNA degradosome for RNA decay
22-Jul-22 Dr.林亮儒  Jason C. elegans: a potential animal model to study how resveratrol isomers affect EndoG in treating  neurodegenerative disease
25-Aug-22楊維仁 Godzella Introduction of several useful functions of Phenix ( case studies of crystal datasets among my side projects)
25-Aug-22張楒潁 Expression and purification of human caspase-activated DNase
31-Aug-22黃薰禾 Daniel Structural and biochemical investigation of the prostate cancer-related mutants of human DNA methyltransferase 3B
05-Sep22Dr.卓昭成 David Structural insights into harmine-mediated inhibition of human DNA methyltrasnferases
16-Sep-22陳誼寧 Moog Cryo-EM image processing detail_use hPNPase-RNA complex as a study case
23-Sep-22Dr. 李宜靜 Yi-Ching Li Cryo-EM single particle analysis of  hPNPase-RNA complex
07-Oct-22江柏辰 Allen Structure of DNMT 3B homo-oligomer reveals vulnerability to impairment by ICF mutations
28-Oct-22呂文廷 Lucia Structural and Biochemical Study of mitochondrial Human endonuclease G
11-Nov-22Dr. Malay Assemble of Multicomponent Machines in RNA metabolic Process: A Common principles in RNA-decay Pathway
18-Nov-22陳怡萍 Ping  Human endonuclease G (WT) reconstruction and purification
25-Nov-22費正尹 Tony Molecular insights into homodimer disassembly and DNA binding defects caused by the ICF syndrome mutations in DNMT3B
09-Dec-22
Dr.林亮儒  Jason Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion
16-Dec-22楊維仁 Godzella  Characterization of hEndoG bound with Trans - Resveratrol
06-Jan-23Dr. 李宜靜 Yi-Ching Li Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization
13-Jan-23Monika Jain Structural and biochemical insights into  mitochondrial RNA degradation by Suv3 helicase 
20-Mar-23呂文廷 Lucia Human Endonuclease G (hEndoG) prefers to cleave gapped DNA, supporting its role in removal of damaged DNA in mitochondria
20-Mar-23黃薰禾 Daniel  Structural and biochemical investigation of the prostate cancer-related mutants of human DNA methyltransferase 3B
07-Jul-23江柏辰 Allen Structural and Biochemical Studies of DNA Methyltransferase (DNMT) Progress Report
13-Jul-23Dr. Malay Structural basis for active monomeric and dimeric suv3 assembly in human mitochondria
20-Jul-23陳怡萍 Ping Reconstruction, purification and crystallization of human CAD-ICAD complex
03-Aug-23楊維仁 Godzella Collaborate on TDP-43 binder design with David Becker’s Lab
17-Aug-23Dr.卓昭成 David Structural and biochemical studies of the regulatory mechanism of human DNA methyltransferase 3B
07-Sep-23Dr. 李宜靜 Yi-Ching Li Cryo-EM single particle analysis of hPNPase-RNA complex
05-Oct-23江柏辰 Allen Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding
12-Oct-23Dr. Malay Structural Insight into mitochondrial RNA decay and surveillance
19-Oct-23陳怡萍 Ping Molecular basis of apoptotic DNA DFF40
26-Oct-23楊維仁 Godzella Collaborate on TDP-43 minibinder proteins design with David Baker’s Lab
09-Nov-23Dr.卓昭成 David Structural and biochemical studies of the regulatory mechanism of human DNA methyltransferase 3B
16-Nov-23陳誼寧 Moog Human Suv3 Cryo-EM data analysis
https://hyuan.imb.sinica.edu.tw/MissingData