|Structural Insights into a Unique Dimeric DEAD-Box|
Helicase CshA that Promotes RNA Decay
|Authors: Jennifer Huen, Chia-Liang Lin,Bagher Golzarroshan, Wan-Li Yi,Wei-Zen Yang, Hanna S. Yuan|
Huen et al. report the crystal structure of CshA, a unique dimeric DEAD-box helicase. CshA binds RNA with or without ATP/ADP, as RNA remain bound with CshA during ATP hydrolysis cycles.
RNA is thus degraded processively through cooperation between exoribonucleases and CshA in the RNA-degrading machinery.
Accession Numbers 5IVL
Huen et al., 2017, Structure 25, 1–13
March 7, 2017 ª 2017 Elsevier Ltd.