Publications

2008

Li, C. -L ,Yang, W. -Z, Chen Y. -P and Yuan* H. S,
Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing.
Nucleic Acid Res. 2008 Advance Access published May 3

2007

Lei, G. -S, Chen, C. -J, Yuan*, H. S, Wang, S -H and Hu, S. -T  

Inhibition of IS2 transposition by factor for inversion stimulation. 

FEMS Microbiol Lett. 275. 98-105,  2007.

 

Huang, H. and Yuan*, H. S. 

The conserved asparagine in the HNH motif plays an important structural role in metal finger endonucleases.  

J. Mol. Biol. 2007  368, 3, 812-821

 

Wang, Y. -T, Yang, Y. -J, Li, C -L, Doudeva, L. G., and Yuan*,H, S.

Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases

Nucleic Acid Res. 2007 35, 2 ,584-594

 

2006

　

Pan, Y.-H., Liao, C.-C., Kuo, C.-C., Duan, K.-J., Liang, P.-H, Yuan*, H. S., Hu, S.-T. and Chak, K.-F.

The critical roles of polyamines in regulating ColE7 production and restricting ColE7 uptake of the colicin-producing Escherichia coli.

J. Biol. Chem. 2006, 281, 13083.

　

Doudeva, L. G., Huang, H., Hsia, K.-C., Shi, Z., Li, C.-L, Cheng, Y.-S. and Yuan*, H. S.

Crystal structural analysis and metal-dependent stability and activity studies of the ColE7 endonuclease domain in complex with DNA/Zn2+ or inhibitor/Ni2+.

Protein Sci. 2006, 15, 269-280.

　

Cheng, Y.-S., Shi, Z., Doudeva, L. G., Yang, W.-Z., Chak, K.-F. and Yuan*, H. S.

High-resolution crystal structure of a truncated ColE7 translocation domain: Implications for colicin transport across membranes.

J. Mol. Biol. 2006, 356, 22-31.

　

2005

　

Hsia, K.-C., Li, C.-L. and Yuan*, H. S.

Structural and functional insight into the sugar-nonspecific nucleases in host defense.

Curr. Opin. Struct. Biol, 2005, 15, 126-134.

 

Liu, H., Peng, H.-W., Cheng, Y.-S. Yuan, H. S. and Yang-Yen*, H.-F.

Stabilization and enhancement of the antiapoptotic activity of Mcl-1 by TCTP.

Mol. Cell. Biol. 2005, 3117–3126.

 

Shi, Z., Chak. K.-F. and Yuan*, H. S.

Identification of an essential cleavage site in ColE7 required for import and killing of cells.

J. Biol. Chem. 2005, 280, 24663-24668.

　　

2004

 

Hsia, K.-C., Chak, K.-F., Liang, P.-H., Cheng, Y.-S., Ku, W.-Y. and Yuan*, H. S.

DNA binding and degradation by the H-N-H protein ColE7

Structure 2004, 12, 205-214.

 

Lin, Y.-H., Liao, C.-C., Liang, P.-H., Yuan, H. S. and Chak*, K.-F

Involvement of colicin in the limited protection of the colicin producing cells against bacteriophage

Biochem. Biophys. Res. Commun. 2004, 318, 81-87.

 

2003

 

Tsai, L.-C., Shyur, L.-F., Lee, S.-H. Lin, S.-S. and Yuan*, H. S.

Crystal structure of a natural circularly-permutated jellyroll protein: 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes.

J. Mol. Biol. 2003, 330, 607-620.

 

Li, C.-L., Hor, L.-I., Chang, Z.-F., Tsai, L.-C., Yang, W.-Z. and Yuan*, H. S.

DNA binding and cleavage by the periplasmic nuclease Vvn- A novel structure with a known active site.

EMBO J. 2003, 22, 4014-4025.

 

2002

　

Chang, S.-J., Hsieh, S.-Y., Yuan, H. S. and Chak*, K.-F.

Characterization of the specific cleavage of ceiE7-mRNA of the bactericidal ColE7 operon.

Biochem. Biophys. Res. Commun. 2002, 299, 613-620.

　

Cheng, Y.-S., Hsia, K.-C., Doudeva, L. G., Kin-Fu Chak and Yuan*, H. S.

The crystal structure of the nuclease domain of colicin E7 suggests a mechanism for binding to double-stranded DNA by the H-N-H endonucleases.

J. Mol. Biol. 2002, 324, 227-236.

　

Sui, M.-J., Tsai, L.-C., Hsia, K.-C., Doudeva, L. G., Ku, W.-Y., Han, G. W. and Yuan*, H. S.

Metal ions and phosphate binding in the H-N-H motif: Crystal structures of the nuclease domain of ColE7/Im7 in complex with a phosphate ion and different divalent metal ions.

Protein Sci. 2002, 11, 2947-2957.

　

Cheng, H.-L., Tsai, L.-C., Lin, S.-S., Yuan, H. S., Yang, N.-S., Lee, S.-H. and Shyur*, L.-F.

Mutagenesis of Trp54 and Trp203 residues on Fibrobacter Succinogens 1,3-1,4-b-D-glucanase significantly affects catalytic activities of the enzyme.

Biochemistry 2002, 41, 8759-8766.

　

Ku, W.-Y., Liu, Y.-W., Hsu, Y.-C., Liao, C.-C., Liang, P.-H., Yuan*, H. S. and Chak*, K.-F.

The zinc ion in the HNH motif of the endonuclease domain of colicin E7 is not required for DNA binding but is essential for DNA hydrolysis.

Nucleic Acid Res. 2002, 30, 1670-1678.
　

Yang Z., Zhang H., Hung H. C., Kuo, C. C., Tsai, L. C., Yuan, H. S., Chou, W. Y., Chang, G. G., Tong*, L.

Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme.

Protein Sci., 2002, 11:332-41.
　

2001

　

Chen, J. L., Tsai, L. C., Wen, T. N., Tang, J. B., Yuan, H. S. and Shyur*, L. F.

Directed mutagenesis of specific active site residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalysis and enzyme structural stability.

J. Biol. Chem. 2001, 276, 17895-17901.

　

Tsai, L. C., Shyur, L. F., Lin, S. S., Yuan*, H. S.

Crystallization and preliminary X-ray diffraction analysis of the 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes.

Acta Cryst. D. 2001, 57, 1303-1306.

　

2000

　

Cheng, Y.-S., Yang, W.-Z., Johnson, R. C. and Yuan*, H. S.

Structure analysis of the transcriptional activation region on Fis: Crystal structures of Six Fis Mutants with Different activation properties.  

J. Mol. Biol. 2000, 302, 1139-1151.

 

1999

　

Ko, T.-P., Liao, C.-C., Ku, W.-Y., Chak, K.-F. and Yuan*, H. S.

The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein.

Structure, 1999, 7, 91-102.

 

Tsai, L.-C, Kuo, C.-C., Chou, W.-Y., Chang, G.-G. and Yuan*, H. S.

Crystallization and preliminary x-ray diffraction analysis of malic enzyme from pigeon liver.

Acta Cryst. D. 1999, 55, 1930-1932.

 

Ko, T.-P., Yang, W.-Z, Wu, S.-P., Hsin, T., and Yuan*, H. S.

The preliminary crystallographic analysis of the open-form E. coli tyrosine aminotransfer ase bound with a cofactor pyridoxal 5'-phosphate.

Acta Cryst. D. 1999, 55, 1474-1477.

 

Lu, F.-M., Yuan, H. S., Hsu, Y.-C., Chang, S.-J., Chak*, K.-F.

Hierarchical order of critical residues on the immunity-determining region of the Im7 protein which confer specific immunity to its cognate colicin.

Biochem. Biophys. Res. Commun. 1999, 264, 69-75.

　

Chang*, S.-L., Chao, C.-H., Huang, Y.-S., Jean, Y.-C., Sheu, H.-S., Liang, F.-J., Chen, C.-K., Yuan, H. S.

Quantitative phase determination for macromolecular crystals using stereoscopic multibeam imaging

Acta. Cryst. A. 1999, 55, 933-938.
　

Hsu, W.-H., Chien, F.-T., Hsu, C.-L., Wang, T.-C., Yuan, H. S., and Wang*, W.-C.

Expression, crystallization and preliminary x-ray diffraction studies of N- carbamyl-D-amino-acid amidohydrolase from Agrobacterium radiobacter.

Acta. Cryst. D. 1999, 55, 694-695.

 

1998

 

Yang, W.-Z, Ko, T. P., Corselli, L., Johnson, R. C. and Yuan*, H. S.

The conversion from a beta-strand to an alph-helix induced by a single-site mutation identified in the crystal structures of Fis mutant Pro26Ala.

Protein Sci. 1998, 7, 1875-1883.

 

1997

 

Safo, M. K., Yang, W.-Z., Corselli, L., Crampton, S., Yuan*, H. S, and Johnson*, R. C.

The transactivation region of the Fis protein that controls site-specific DNA inversion contains extended mobile beta-hairpin arms.

EMBO J. 1997, 16, 6860-6873.

 

Hsieh, S.-H., Ko, T.-P., Tseng, M.-Y., Ku, W.-Y., Chak*, K.-F, and Yuan*, H. S.

A novel role of ImmE7 in the autoregulatory expression of ColE7 operon and identification of possible ribonuclease active sites in the crystal structure of dimeric ImmE7.

EMBO J. 1997, 16, 1444-1454.


1996

 

Chak, K.-F., Safo, M. K., Ku, W.-Y., Hsieh, S.-Y., and Yuan*, H. S.

The crystal structure of the ImmE7 protein suggests a possible colicin-interacting surface.

Proc. Natl. Acad. Sci. USA, 1996, 93, 6437-6442.

1995

 

Ku, W.-Y., Wang, C. S., Chen, J. Y., Chak, K.-F., Safo, M. K., and Yuan*, H. S.

Crystallization and preliminary crystallographic analysis of ImmE7 protein of Colicin E7.

Proteins, Struc. Func. & Genet. 1995, 23, 588-590.

 

1994

 

Yuan*, H. S., Yang, W.-Z., Wang, S. S., Finkel, S. E. and Johnson, R. C.
The structure of Fis mutant Pro61-Ala illustrates that the kink within the long a-helix is not due to the presence of the proline residue.

J. Biol. Chem. 1994, 269, 46, 28947-28954.

Yuan, H. S., Stevens, R. C., Kotzle, T. F. and Bau*, R

Determination of the absolute configuration of (S)-(+)-neopentyl-1-d alcohol by neutron diffraction study of strychnium neopentylphthalate.

Proc. Natl. Acad. Sci. USA 1994, 91, 12872-12876.